Cheng Kao
Professor, Molecular and Cellular Biochemistry Department
Education
BS, Microbiology and Biology, University of Michigan
PhD, Microbiology, Michigan State University
Research
We are interested in both basic and applied studies of how RNA viruses interact with the host cell. The lab has three interrelated areas of focus, and these have the potential to enrich each other.
Representative Publications
Goicochea, N. L., S. A. K. Datta, A. Rein, M. Ayaluru, C. C. Kao, Bogdan Dragnea. 2011. Structural properties of template-directed recombinant HIV-1 GAG particles.
Huang, X., Stein, B., Cheng, H., Malyutin, A., Tsvetkova, I., Baxter, D., Remmes, N., Verchot, J., Kao, C., Bronstein, L., and Dragnea, Bogdan. 2011. Magnetic virus-like nanoparticles in N. benthamiana plants a new paradigm for environmental and agronomic biotechnological research. ACS Nano. In press.
Qi X., T. Droste, and C. C. Kao. 2011. Cell-penetrating peptides derived from viral capsid Proteins. Molec. Plant-Microbe Interact. 24:25-36.
Ranjith-Kumar C. T., Y. Y. Lai, R. T. Sarisky, and C. C. Kao. 2010 Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. PLoS One 5(9): e12878. doi:10.1371/journal.pone.0012878.
Lu C., C.T. Ranjith-Kumar, L. Hao, C. C. Kao, and P. Li. 2010. Crystal structure of human RIG-I C-terminal domain bound to a blunt-ended double-stranded RNA. NAR 2010, 1-11.
Hwang J., L. Huang, D. G. Cordek, R. Vaughan, S. L. Reynolds, G. Kihara, K. D. Raney, C. Cheng Kao, and C. E. Cameron. 2010. Hepatitis C virus nonstructural protein 5A (NS5A): biochemical characterization of a novel structural class of RNA-binding proteins. J. Virol. 84:12480-12491.
Qi, R. S. Hoose, J. Schreiter, K. V. Sawant, R. Lamb, C.T. Ranjith-Kumar, J. Mills, L. San Mateo, J. L. Jordan, and C. C. Kao. 2010. Secretion of the human Toll-like Receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by UNC93B. J. Biol. Chem. 285:36635-36645.
Qi X., T. Droste, and C. C. Kao. 2010. Cell-penetrating peptides derived from viral capsid Proteins. Molec. Plant-Microbe Interact. 24:25-36.
Ortiz-Alcantara, J. K. Bhardwaj, S. Palaninathan, M. Frieman, R. S. Baric, C. C. Kao. 2010. Small molecule inhibitors of the SARS-CoV nsp15 endoribonuclease. Virus Adaptation and Treatment. Virus Adaptation and Treatment 2010:125-133.
Lu C., H. Xu, C.T. Ranjith-Kumar, M. T. Brooks, T. Y. Hu, A. B. Herr, R. K. Strong, C. Cheng Kao, and P. Li. 2010. The structural basis of 5' triphosphate double-stranded RNA recognition by the RIG-I C-terminal domain. Structure 18, 1-12.
Daniel M.-C., I. Tsvetkova, Z. Quinkert, A. Murali, M. De, V. L. Rotello, C. C. Kao, and B. Dragnea. 2010. Critcal surface charge density is required for nanoparticle-templated assembly by bromovirus protein cages. ACS-Nano 4. 3853-3860.
Hema, M., A. Murali, K. Fujisaki, I. Tsvetkova, P. Ni, R. C. Vaughan, B. Dragnea, and C. Cheng Kao. 2010. A single amino acid substitution in the brome mosaic virus capsid protein resulted in biased RNA packaging. Molec. Plant Microb. Interact. 23:1433-1447.
